Estrogen regulates myogenic tone in hippocampal arterioles by enhanced basal release of nitric oxide and endothelial SKCa channel activity.
Jeffrey DA, Russell A, Bueno Guerrero M, Fontaine JT, Phinea Romero P, Rosehart AC, Dabertrand F.
bioRxiv 2023; 10.1101/2023.08.15.553442. PMID: 37645715

Ex vivo capillary-parenchymal arteriole approach to study brain pericyte physiology 
Jeffrey DA, Fontaine JT, Dabertrand F.
Neurophotonics 2022; 9(3), 031919. PMID: 36278784

PIP₂ corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity
Dabertrand F^†*, Harraz OF^†, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT*.
Proc. Natl. Acad. Sci. U.S.A. 2021;118(17):e2025998118. *Equal contribution; ^†co-corresponding authors PMID: 33875602

Prostaglandin E₂ dilates intracerebral arterioles when applied onto capillaries: Implications for small vessel diseases
Rosehart AC, Longden TA, Weir N, Fontaine JT, Joutel A, Dabertrand F.
Front. Aging Neurosci. 2021;13:695965. PMID: 34483880

Capillary K⁺-sensing initiates retrograde hyperpolarization to locally increase cerebral blood flow
Longden TA*, Dabertrand F*, Koide M, Gonzales AL, Tykocki NR, Brayden JE, Hill-Eubanks D, Nelson MT.
Nat. Neurosci. 2017;10.1038/nn.4533. *Equal contribution. PMID: 28319610

Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease
Dabertrand F, Krøigaard C, Bonev AD, Cognat C, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT.
Proc. Natl. Acad. Sci. U.S.A. 2015; 17;112(7):E796-805. PMID: 25646445

Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels
Dabertrand F, Nelson MT, Brayden JE.
Circ. Res. 2012; 20;110(2):285-9. PMID: 22095728

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Harnessing micrometer-scale tPA beads for high plasmin generation and accelerated fibrinolysis
Osmond JM, Dabertrand F, Quillinan N, Su EJ, Lawrence DA, Marr DWM, Neeves KB.
bioRxiv 2024; 10.1101/2024.11.06.621942

Sweet relief: make the brain Glo against diabetic cognitive fog
Dabertrand F.
J. Physiol. 2024; doi: 10.1113/JP287622. PMID: 39405447

Activity-dependent regulation of vascular cholesterol metabolism acts as a negative feedback mechanism for neurovascular coupling
Profaci CP, Foreman KL, Spieth L, Coelho-Santos V, Berghoff SA, Fontaine JT, Jeffrey DA, Palecek SP, Shusta EV, Saher G, Shih AY, Dabertrand F^†, Daneman R ^†.
bioRxiv 2024; 10.1101/2024.02.23.581685 ^†co-corresponding authors

Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism
Profaci CP, Harvey SS, Bajc K, Zhang TZ, Jeffrey DA,  Zhang AZ, Nemec KM, Davtyan H, O’Brien CA, McKinsey GL, Aaron Longworth, McMullen TP, Capocchi JK, Gonzalez JG, Lawson DA, Arnold TD, Davalos D, Blurton-Jones M, Dabertrand F, Bennett FC, Daneman R.
Neuron. 2024; S0896-6273(24)00537-3. PMID: 39142282

Endothelial cell calcium influx mediates trauma-induced endothelial permeability
Schaid TR, Mitra S, Stafford P, DeBot M, Thielen O, Hallas W, Cralley A, Gallagher L, Jeffrey DA, Hansen K, D’Alessandro A, Silliman CC, Dabertrand F, Cohen MJ.
Annals of Surgery 2003; 10.1097/SLA.0000000000006164. PMID: 38073572

Estrogen regulates myogenic tone in hippocampal arterioles by enhanced basal release of nitric oxide and endothelial SKCa channel activity.
Jeffrey DA, Russell A, Bueno Guerrero M, Fontaine JT, Phinea Romero P, Rosehart AC, Dabertrand F.
bioRxiv 2023; 10.1101/2023.08.15.553442. PMID: 37645715

Ex vivo capillary-parenchymal arteriole approach to study brain pericyte physiology
Jeffrey DA, Fontaine JT, Dabertrand F.
Neurophotonics 2022; 9(3), 031919. PMID: 36278784

Prostaglandin E₂ dilates intracerebral arterioles when applied onto capillaries: Implications for small vessel diseases
Rosehart AC, Longden TA, Weir N, Fontaine JT, Joutel A, Dabertrand F.
Front. Aging Neurosci. 2021;13:695965. PMID: 34483880

Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease
Koide M, Harraz OF, Dabertrand F, Longden TA, Ferris HR, Wellman GC, Hill-Eubanks, DC, Greenstein AS, Nelson MT.
Clin. Invest. 2021;131(18):149029. PMID: 34351870

PIP₂ corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity
Dabertrand F^†*, Harraz OF^†, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT*.
Proc. Natl. Acad. Sci. U.S.A. 2021;118(17):e2025998118. *Equal contribution; ^†co-corresponding authors PMID: 33875602

HB-EGF depolarizes hippocampal arterioles to restore myogenic tone in a genetic model of small vessel disease
Fontaine JT, Rosehart AC, Joutel A, Dabertrand F.
Mech. Ageing Dev. 2020; 192:111389. PMID: 3312744

The capillary Kir channel as sensor and amplifier of neuronal signals: modeling insights on K⁺-mediated neurovascular communication
Moshkforoush A, Ashenagar B, Harraz OF, Dabertrand F, Longden TA, Nelson MT, Tsoukias NM.
Proc. Natl. Acad. Sci. U.S.A. 2020; 117(28):16626-16637. PMID: 32601236

Reducing hypermuscularization of the transitional segment between arterioles and capillaries protects against spontaneous intracerebral hemorrhage
Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Al-Shahi Salman R, Smith C, Gerbeau JF, Nelson MT, Joutel A.
Circulation. 2020; 141(25):2078-2094. PMID: 32183562

Ex vivo pressurized hippocampal capillary-parenchymal arteriole preparation for functional study
Rosehart AC, Johnson AC, Dabertrand F.
Vis. Exp. 2019; 18;(154). PMID: 31904015

Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP₂ depletion
Harraz OF, Longden TA, Dabertrand F, Hill-Eubanks D, Nelson MT.
Proc. Natl. Acad. Sci. USA. 2018; 115(15):E3569-E3577. PMID: 29581272

Changes in cerebral arteries and parenchymal arterioles with aging: role of rock2 and impact of genetic background
De Silva MT, Modrick ML, Dabertrand F, Faraci FM.
Hypertension. 2018; 75(5):921-27. PMID: 29531174

The yin and yang of K_V channels in cerebral small vessel pathologies
Koide M, Moshkforoush A, Tsoukias MT, Hill-Eubanks D, Wellman GC, Nelson MT, Dabertrand F.
Microcirculation. 2018; 25(1):e12436. Invited review. PMID: 29247493

Capillary K⁺-sensing initiates retrograde hyperpolarization to locally increase cerebral blood flow
Longden TA*, Dabertrand F*, Koide M, Gonzales AL, Tykocki NR, Brayden JE, Hill-Eubanks D, Nelson MT.
Nat. Neurosci. 2017;10.1038/nn.4533. *Equal contribution. PMID: 28319610

Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics
Capone C, Dabertrand F, Baron-Menguy C, Chalaris A, Ghezali L, Domenga-Denier V, Schmidt S, Huneau C, Rose-John S, Nelson MT, Joutel A.
eLife. 2016;10.7554/eLife.17536. PMID: 27476853

Isolation and cannulation of cerebral parenchymal arterioles
Pires PW, Dabertrand F, Earley S.
Vis. Exp. 2016; 23;(111). PMID: 27286481 

Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease
Dabertrand F, Krøigaard C, Bonev AD, Cognat C, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT.
Proc. Natl. Acad. Sci. U.S.A. 2015; 17;112(7):E796-805. PMID: 25646445

Blood brain barrier precludes the cerebral arteries to intravenously-injected antisense oligonucleotide
Boursereau R, Donadieu A, Dabertrand F, Dubayle D, Morel JL.
Eur. J. Pharmacol. 2014; 13;747C:141-149. PMID: 25510229

A PLCγ1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries
Gonzales AL, Yang Y, Sullivan MN, Sanders L, Dabertrand F, Hill-Eubanks DC, Nelson MT, Earley S.
Sci. Signal. 2014; 27;7(327):ra49. PMID: 24866019

Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular Kir channel function
Longden TA, Dabertrand F, Hill-Eubanks D, Hammack SE, Nelson MT.
Proc. Natl. Acad. Sci. U.S.A. 2014; 20;111(20):7462-7. PMID: 24808139

Up-regulation of ryanodine receptor expression increases the calcium-induced calcium release and spontaneous calcium signals in cerebral arteries from hindlimb unloaded rats
Morel JL*, Dabertrand F*, Porte Y, Prevot A, Macrez N.
Pflugers Arch. 2014; 466(8):1517-28. *Equal contribution. PMID: 24233561

Prostaglandin E₂, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles
Dabertrand F, Hannah RM, Pearson JM, Hill-Eubanks DC, Brayden JE, Nelson MT.
Cereb. Blood Flow Metab. 2013; 33(4):479-82. PMID: 23385200

Ryanodine receptors, calcium signaling and regulation of vascular tone in the cerebral parenchymal microcirculation
Dabertrand F, Nelson MT, Brayden JE.
Microcirculation. 2013; 20(4):307-16. Invited review. PMID: 23216877

Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels
Dabertrand F, Nelson MT, Brayden JE.
Circ. Res. 2012; 20;110(2):285-9. PMID: 22095728

Spaceflight regulates ryanodine receptor subtype 1 in portal vein myocytes in the opposite way of hypertension
Dabertrand F, Porte Y, Macrez N, Morel JL.
Appl. Physiol. 2012; 112(3):471-80. PMID: 22096120

Comparison between gentamycin and exon skipping treatments to restore ryanodine receptor subtype 2 functions in mdx mouse duodenum myocytes
Dabertrand F, Mironneau J, Henaff M, Macrez N, Morel JL.
Eur. J. Pharmacol. 2010; 25;628(1-3):36-41. PMID: 19944091

The decrease of expression of ryanodine receptor subtype 2 is reversed by gentamycin sulfate in vascular myocytes from mdx mouse
Morel JL, Dabertrand F, Fritz N, Henaff M, Mironneau J, Macrez N.
Cell. Mol. Med. 2009; 13(9B):3122-30. PMID: 19298530

Acetylcholine evokes an InsP3R1-dependent transient Ca²⁺ signal in rat duodenum myocytes
Fritz N, Dabertrand F, Mironneau J, Macrez N, Morel JL.
Can. J. Physiol. Pharmacol. 2008; 86(9):626-32. PMID: 18758512

Full length ryanodine receptor subtype 3 encodes spontaneous calcium oscillations in native duodenal smooth muscle cells
Dabertrand F, Mironneau J, Macrez N, Morel JL.
Cell Calcium. 2008; 44(2):180-9. PMID: 18207571

Strain differences in hypothalamic pituitary adrenocortical axis function and adipogenic effects of corticosterone in rats
Marissal-Arvy N, Gaumont A, Langlois A, Dabertrand F, Bouchecareilh M, Tridon C, Mormede P.
Endocrinol. 2007; 195(3):473-84. PMID: 18000309

Role of RYR3 splice variants in calcium signaling in mouse nonpregnant and pregnant myometrium
Dabertrand F, Fritz N, Mironneau J, Macrez N, Morel JL.
Am. J. Physiol. Cell Physiol. 2007; 293(3):C848-54. PMID: 17596299

Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells
Dabertrand F, Morel JL, Sorrentino V, Mironneau J, Mironneau C, Macrez N.
Cell Calcium. 2006; 40(1):11-21. PMID: 16678258